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ORIGINAL ARTICLE - EVALUATIVE STUDY
Year : 2019  |  Volume : 9  |  Issue : 2  |  Page : 253-256

Effect of Kenacort on pregnant Wistar albino rats


Department of Anatomy, Shri Sathya Sai Medical College and Hospital, Sri Balaji Vidyapeeth University (deemed to be university), Kancheepuram, Tamil Nadu, India

Correspondence Address:
Julie Christy Amalraj
No. 9 Ganga Cauvery Street, Ramakrishna Nagar Extn, Porur, Chennai - 600 116, Tamil Nadu
India
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DOI: 10.4103/ams.ams_141_16

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Kenacort is a well-known synthetic glucocorticoid used in today's medical practice for various therapeutic uses. The drug has been known to induce cleft palate in rodents in specific doses. This study uses triamcinolone acetonide (TAC) as a teratogen for inducing cleft palate in rat embryos. The study discusses the molecular level action of TAC on the palatal mucosa in the rat palate. This study substantiates that the TAC given during the first trimester between 29th and 38th day of gestation can induce many congenital anomalies. The study shows an animal model to depict the drug toxicity on the pregnant Wistar albino rats.


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